Effects of individual characteristics on healthy oral mucosa autofluorescence spectra.

Autofluorescence and diffuse reflectance spectroscopy for oral oncology.

BACKGROUND AND OBJECTIVES Autofluorescence and diffuse reflectance spectroscopy have been used separately and combined for tissue diagnostics. Previously, we assessed the value of autofluorescence spectroscopy for the classification of oral (pre-)malignancies. In the present study, we want to determine the contributions of diffuse reflectance and autofluorescence spectroscopy to diagnostic perf...

Autofluorescence characteristics of healthy oral mucosa at different anatomical sites.

BACKGROUND AND OBJECTIVES Autofluorescence spectroscopy is a promising tool for oral cancer detection. Its reliability might be improved by using a reference database of spectra from healthy mucosa. We investigated the influence of anatomical location on healthy mucosa autofluorescence. STUDY DESIGN/MATERIALS AND METHODS Spectra were recorded from 97 volunteers using seven excitation waveleng...

Clinical study for classification of benign, dysplastic, and malignant oral lesions using autofluorescence spectroscopy.

Autofluorescence spectroscopy shows promising results for detection and staging of oral (pre-)malignancies. To improve staging reliability, we develop and compare algorithms for lesion classification. Furthermore, we examine the potential for detecting invisible tissue alterations. Autofluorescence spectra are recorded at six excitation wavelengths from 172 benign, dysplastic, and cancerous les...

Grading of Oral Mucosa by Curve-fitting of Corrected Autofluorescence Spectra

Variability of spectra of laser-induced fluorescence of colonic mucosa: its significance for fluorescence detection of colonic neoplasia.

To determine the extent of a natural variability of the spectra of the autofluorescence and its significance for a reproducibility of different approaches typically used in studies on fluorescence detection of colonic lesions. Two independent series of experiments have been conducted during three years in the same laboratory. Macroscopic tissue specimens obtained during operations of patients w...